Dermatologist Recommended Top Rated Anti-Aging Wrinkle Creams of 2021


Last Updated: Apr 18, 2022

Choosing the right Anti-Wrinkle Cream for your aging skin is a key strategy that can help you win or lose your battle against wrinkles and fine lines. Here is a quick reference on the best anti-aging creams and what kind of care your skin needs.

Top Rated Anti-Aging Wrinkle Creams 2021

Dermology Anti Aging


This anti-aging cream is made up Matrixyl 3000 and Argireline as its two primary ingredients. It visibly plumps and firms up your skin with a significant collagen boost, softening your wrinkles and vanishing fine lines. Argireline is a peptide that relaxes your facial muscles so your skin can stretch back to its pre-expression state. Full Dermology Review
Price: $29.99, 1 fl. oz.

Kollagen Intensiv


With SYN-COLL in the formula, this product helps your damaged skin heal faster while effectively strengthening your skin. With antioxidants, SYN-COLL to helps your skin fight signs of future damage and aging. Added vitamins and Shea Butter replenish vital nutrients that your skin needs to be renewed and rejuvenated. Full Kollagen Review
Price: $59.95, 1 fl. oz.



All products from this brand carry the proprietary ingredient its founders have formulated, NIA-114. This revolutionary skincare technology fights wrinkles and other signs of skin aging by refortifying the skin’s protective barrier function. By rebuilding the skin’s surface, your skin becomes denser, fuller, firmer. Full StriVectin SD Review
Price: $89 for 1.7 oz. of StriVectin Radiance Refining Moisturizer.

Olay Regenerist


Regenerist is one of several highly specialized anti-aging products from Olay, the brand that pioneered anti-aging care since 1949. Niacinamide floods your skin with antioxidants, improves local circulation, and promotes a more even skin tone. Peptides and olive oil extract help restore your skin’s fullness by replenishing collagen and moisture. Full Olay Regenerist Review
Price: $15 for 50 g of Olay Regenerist Advanced Anti-aging Night Firming Cream

What is Anti Aging Cream


An anti-aging cream is a product applied to aging areas of your skin. Its primary functions are to restore hydration and moisture. Advanced skin care technologies now permit skin to be restructured, regenerated and renewed with the help of these creams.

What are the Benefits of Anti-Aging Cream


Based on a study published in the Journal of Dermato Endocrinology in 2012, an anti aging cream may be composed of one or more of the following anti-aging agents which differentiate the benefits that can be derived from each:


Antioxidants promote skin health and deliver anti-aging benefits by guarding your skin cells against the degrading and damaging effects of free radicals. If left unchecked, free radicals attack your skin cells, degrades collagen, and significantly slows down natural skin mechanisms for repair, regeneration and renewal.

Cell regulators

These group of anti-aging skin agents directly affect how your skin cells function. Ingredients such as retinol and peptides stimulate skin cells to produce more skin precursors that enable faster skin healing and recovery from damage. Thus, these two are considered as cell regulators. Recent evidence about the effectiveness of plant stem cells for anti-aging skin care highlight that these, too, are cell regulators.

When Should You Start Using Wrinkle Creams


Dermatologist, Dr. Surbhi, writes on Dermatocare, that the best time to be on an anti-wrinkle cream is after you turn 25. She adds that you should, however, get started early on sunscreen. When you experience premature aging, you may start earlier on your anti-aging regimen.

Types Of Anti-Wrinkle Creams

Based on the active ingredients found in wrinkle creams, these generally contain one or more of the following ingredients:

Stem Cells

Among the Best Anti-Wrinkle Creams presently are those that contain high performing plant-derived stem cells. These stimulate skin healing but, have also been found to protect skin fibers, including collagen and elastin, from becoming degraded. Use suits any skin age where premature aging is prominent.

Vitamin A

Probably the most studied and most established anti-aging ingredient, Vitamin A and its derivatives, including tretinoin and retinol, force your skin to turnover faster so that regeneration and renewal can begin. Vitamin A works beyond wrinkles, it also inhibits melanin, the pigment that gives color to your skin, to lighten dark marks and enhance your skin’s radiance. Use for 40s skin and older.


Some wrinkle creams serve a more protective function when powerful antioxidants serve as its key ingredients. These products protect your skin cells from being overrun by cell-damaging free radicals, and helps keep the integrity of your skin fibers to maintain a strong bond that protects against degradation. These wrinkle creams best suit over 25 up to early 40s skin.

Moisturizers and Hyaluronic Acid

These ingredients improve your skin’s density and volume, plumping your skin to add fullness that softens the appearance of wrinkles and fine lines. These moisturizers work well for younger skin types.

Does Anti Aging Creams Cause Side Effects?

It is possible for an Anti-Wrinkle Cream to cause side effects, depending on two things: the ingredients that make up its formula, and your skin’s level of sensitivity. In general highly sensitive and reactive skin types do not tolerate retinol and other Vitamin A derivatives well. First time users are advised to work up to desired concentration of Vitamin A to help skin adjust to the formula. Long-term use has also been found to cause skin to become thinner and more sensitive to sun damage.

Artificial fragrances and synthetic dyes added to anti-aging creams can also cause skin irritations. The most common preservatives added to wrinkle creams can cause toxic effects to the body, while some can affect your estrogen levels.

How To Choose The Best Anti-Wrinkle Cream


To get the wrinkle cream that best fits your skin, consider your age and your skin type:

  • If you’re around 25 without signs of prematurely aging skin, you should start with creams that deliver added moisture and antioxidants only.
  • If you’re 40 and older or, experiencing premature skin aging, try a Vitamin A laden product. Stem cells also provide a viable option.
  • If you’re over 40 and have sensitive or reactive skin , try stem cells.

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