SkinMedica HA5 Rejuvenating Hydrator Reviews – Should You Trust This Product?

SkinMedica HA5 Rejuvenating Hydrator gives patients instant smoothing gratification and supports skin health through replenishment of the skin's own HA.
By - Updated April 25, 2022

What Is SkinMedica HA5 Rejuvenating Hydrator?

SkinMedica HA5 Rejuvenating Hydrator is an instant wrinkle cream smoothening solution that fills in the creases and plumps your skin to make your skin surface appear smoother and more even but may cause irritation on applied area.

This product is brought to you by SkinMedica, a skincare label now owned and managed by Allergan, a pharmaceutical company. When it comes to loving your skin with a formula that has a strong R&D basis, SkinMedica commits to that. The brand was founded in 1999 by Dr. Richard Fitzpatrick before it was bought by Allergan in 2012.

Pros and Cons of SkinMedica HA5 Rejuvenating Hydrator

HA5 Rejuvenating Hydrator

  • Form:Cream
  • Type:All Skin Type
  • Benefit:Reduces The Appearance Of Fine Lines & Wrinkles Refines Skin Texture & Eliminates Roughness
  • Ingredients:HA5, Algin, Polysaccharides, Antioxidants
  • Brand:SkinMedica
  • Weight:1 fl oz (28.4 g)


  • HA5 Rejuvenating Hydrator delivers skin plumping effect while seriously boosting your skin’s moisture content at the same time but it may cause irritation on skin.
  • According to customer reviews skin becomes smoother and looking refreshed.


  • This product is significantly more expensive than most other products that are similarly formulated and that have been demonstrated to instantly plump skin and smoothen out wrinkles just as well as this product does.
  • SkinMedica HA5 Rejuvenating Hydrator reviews indicate that not all skin types, particularly the drier ones, may find this product sufficiently moisturizing.

SkinMedica HA5 Rejuvenating Hydrator – Does It Really Work?

Based on claims made by the manufacturer, this product has been formulated to deliver for you the following benefits:

  • Noticeably smoothen and even out your skin’s surface, making wrinkles and fine lines practically vanish and appear softer.
  • Refresh and restore your skin’s vitality to make it appear more youthful.
  • Replenish your skin’s lost moisture in an instant.
  • Help restore your skin’s capability to capture moisture and keep it locked into your skin.
  • Leave your skin with a silkier feel.

What are the Ingredients in SkinMedica HA5 Rejuvenating Hydrator?

HA5: It is a skin hydrating complex that consists of five key ingredients that cause your skin to become hyper hydrated, that includes five derivatives of hyaluronic acid that deliver different forms of moisturizing for your skin.

Serin: Significantly restores your skin’s moisture content while simultaneously strengthening your skin to make it more resilient to factors that cause your skin damage and aging.

Algin: An algae extract that helps restore your skin’s optimal hydration mechanisms to keep your skin stay moisturized round-the-clock [1].

Polysaccharides: Improve your skin’s liveliness and dewiness which helps restore that youthful, more vibrant look. However, it leads to burning or irritation on the skin [2].

Antioxidants: It revives and revitalizes your skin even as it protects your skin [3].

How To Apply SkinMedica HA5 Rejuvenating Hydrator?

  • HA5 Rejuvenating Hydrator must be used on skin that has freshly cleansed and toned.
  • Apply day and night.
  • Make sure to layer with a broad spectrum sunscreen in the morning.

Does SkinMedica HA5 Rejuvenating Hydrator Have Any Side Effects?

Based on the ingredients and reviews, the following side effects may be experienced when using SkinMedica HA5 Rejuvenating Hydrator:

  • Skin irritation and allergic reactions due to several ingredients, including butylene glycol.
  • Increased risk for developing various forms of cancers due to PEGs.
  • Increased risk for disorders associated with reproductive organs due to EDTA.
  • Increased risk for neurotoxicity due to phenoxyethanol.


Que: Is HA5 a moisturizer?
Ans: No, HA5 Rejuvenating Hydrator is not a moisturizer.

Que: Is ha5 hyaluronic acid?
Ans: Yes, It contains 2 forms of hyaluronic acid.

Que: How long does a bottle of SkinMedica HA5 last?
Ans: A bottle of SkinMedica HA5 lasts about 6 weeks.

Que: Where can I buy this product?
Ans: Visit the company’s website and place your order.

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Final Verdict: SkinMedica HA5 Rejuvenating Hydrator

The makers of SkinMedica HA5 Rejuvenating Hydrator have clearly shown clinical evidence that this product delivers what it says it does, combining both instant and longer-term skin smoothening benefits in one treatment solution. It isn’t the only one in the market though and, chances are, you just might find one that will be formulated similarly and perform similarly without the hefty price tag.

As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.

Below you'll find some of the most effective wrinkle cream formulations on the market today, in our opinion.


Our Top Wrinkle Creams Products

#1. Gle Skincare for Wrinkles

Overall Grade: A+
Gle Skincare for Wrinkles Editor Rating Learn More >>
Improve Skin Elasticity and Firmness*
Hydrating the Area Around the Eye*
Reduces the Appearance of Wrinkles*
Reduces Puffiness*
Delays Skin Aging*
Ingredient Safety
Projected Effectiveness
Return Policy
Customer Satisfaction
Overall Rating 4.9/5


  • The ingredients have high penetrating abilities
  • Protects skin tone from photo-aging
  • All products are Cruelty-Free and Hypoallergenic.
  • Slow down further signs of aging
  • Made in the USA
  • Prevents New blemishes to form


  • Different skin types may experience different results

Customer Review & Rating: 4.9/5

"I love Gle Skincare cream! I've tried the high-end moisturizers and this beats them by far! My skin gets very dry, almost scaly in the winter months. I put this on at night and it soaks in completely so by the morning my skin has a beautiful glow!" - By Krystyna Rudwell


Our current ranking showed that Gle for Wrinkles cream successfully targets stubborn wrinkles around the forehead, the eyes, and the areas around the mouth. The product is made from all-natural ingredients and easily blends makeup and other products. The formula includes Panthenol, Algae Extracts, Tocopherol, and Squalene.

Check Price >>

#2. Dermaset Anti Aging 3D Renewal Cream

Overall Grade: A
Dermaset Anti Aging 3D Renewal Cream Editor Rating Learn More >>
Eliminates the Appearance of Fine Lines*
Instantly Tightens Skin*
Reduces the Appearance of Crow's Feet*
Reduces Puffiness Around Eyes*
Restore Damaged Aging Skin*
Ingredient Safety
Projected Effectiveness
Return Policy
Customer Satisfaction
Overall Rating 4.8/5


  • Natural Ingredients
  • Enhance the overall skin condition
  • The product is Hypoallergenic
  • Clinically Tested Ingredients
  • Botox Free


  • Due to popularity, sometimes it’s on backorder/sold out

Customer Review & Rating: 4.8/5

"Like how nice it makes my skin feel. Dermaset---a great moisturizer for both men and women. Men also care about how they look we just don’t let anyone know. Great product." - By Rhona Henrichs


Customers have witnessed instant firm & tightness in the skin and have shared overwhelming feedback about DermaSet Anti-Aging 3D Renewal Cream. Customers have agreed that the ingredients like hyaluronic acid, vitamin C & plant stem cells in the product deeply penetrate the skin to stop signs of aging and wrinkles in their tracks which continuously helps to repair and restore damaged aged skin.

Check Price >>

#3. Skinception - Instant Wrinkles Reducer

Overall Grade: A
Skinception - Instant Wrinkles Reducer Editor Rating Learn More >>
Improves Skin Elasticity*
Smoothens Fine Lines*
Tightens the Skin*
Deeply Hydrates the Skin*
Improves Skin Firmness*
Ingredient Safety
Projected Effectiveness
Return Policy
Customer Satisfaction
Overall Rating 4.8/5


  • Have visible results without needles
  • Look younger instantly
  • Skin lightening properties
  • Made in the USA
  • All-natural wrinkle treatment
  • Effectively reduces under-eye bags


  • The results disappear in 8 hours; they don’t last for some users

Customer Review & Rating: 4.8/5

"Still no wrinkles! Thanks so much, Skinception! ~ I started using Skinception almost 2 years ago when I was 40. My skin has looked fantastic since I started, and despite my age, I still have not developed a single wrinkle. I attribute this largely to Skinception because I do have a high-stress life. Apparently, the secret to staying young and fresh-looking is Skinception! I highly recommend this anti-aging product to any woman who is concerned about preserving her skin over time. The ingredients are completely natural. I guarantee this product will make you look and feel at least 10 years younger. People will notice! This is a terrific cream." - By Amelia


Customers are sharing their overwhelming reviews that the Skinception Instant Wrinkle Reducer cream has made them look younger from the first week of use. The Hyaluronic Acid in the cream has worked efficiently in lessening the signs of aging smoothly.

Check Price >>

Customer Reviews for HA5 Rejuvenating Hydrator

SkinMedica HA5 Rejuvenating Hydrator Reviews – Should You Trust This Product?
Reviewer Rating
2.6 / 5.0

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The Beauty Insiders takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable, and trustworthy.

[1] Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci. 2012;37(1):106-126. doi:10.1016/j.progpolymsci.2011.06.003
[2] Miao T, Wang J, Zeng Y, Liu G, Chen X. Polysaccharide-Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside. Adv Sci (Weigh). 2018;5(4):1700513. Published 2018 Jan 8. doi:10.1002/advs.201700513